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Vidofludimus
- 4SC-101 - SC 12267
- Soluble in DMSO
- MF: C20H18FNO4
- MW: 355.36
Description
More Information
| Parent CAS No. | 717824-30-1 |
|---|---|
| Chemical Name | 2-(3-fluoro-3'-methoxybiphenyl-4-ylcarbamoyl)cyclopent-1-enecarboxylic acid |
| SMILES | C1(NC(=O)C2CCCC=2C(O)=O)C=CC(C2C=C(OC)C=CC=2)=CC=1F |
| MFCD | MFCD18633262 |
| InChi | InChI=1S/C20H18FNO4/c1-26-14-5-2-4-12(10-14)13-8-9-18(17(21)11-13)22-19(23)15-6-3-7-16(15)20(24)25/h2,4-5,8-11H,3,6-7H2,1H3,(H,22,23)(H,24,25) |
| InChiKey | XPRDUGXOWVXZLL-UHFFFAOYSA-N |
| CID | 9820008 |
| Short Description | DHODH inhibitor |
References
- J. Leban et al. SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors. Bioorg. Med. Chem. Lett. 2005, 15, 4854-4857.
- K. Rusai et al. Immunosuppression with 4SC-101, a novel inhibitor of dihydroorotate dehydrogenase, in a rat model of renal transplantation. Transplantation. 2012, 93, 1101-1107.
- L.R. Fitzpatrick et al. Vidofludimus inhibits colonic interleukin-17 and improves hapten-induced colitis in rats by a unique dual mode of action. J. Pharmacol. Exp. Ther. 2012, 342, 850-860.
- L.R. Fitzpatrick et al. Inhibition of IL-17 as a pharmacological approach for IBD. Int. Rev. Immunol. 2013, 32, 544-555.
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