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Laquinimod
- ABR 215062
Axon 1970
CAS:
248281-84-7
Purity:
99%
- Soluble in DMSO
- MF: C19H17ClN2O3
- MW: 356.8
Description
A selective autoimmune suppressant investigated as an oral treatment for multiple sclerosis (MS) and other autoimmune diseases; Immunomodulator
More Information
| Parent CAS No. | 248281-84-7 |
|---|---|
| Chemical Name | 5-chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide |
| SMILES | N1(C)C2=C(C(Cl)=CC=C2)C(O)=C(C(N(CC)C2=CC=CC=C2)=O)C1=O |
| MFCD | MFCD08689859 |
| InChi | InChI=1S/C19H17ClN2O3/c1-3-22(12-8-5-4-6-9-12)19(25)16-17(23)15-13(20)10-7-11-14(15)21(2)18(16)24/h4-11,23H,3H2,1-2H3 |
| InChiKey | GKWPCEFFIHSJOE-UHFFFAOYSA-N |
| CID | 54677946 |
| Short Description | Immunosuppressant |
References
- G Comi et al. Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet 2008, 371(9630), 2085-2092.
- JS Yang et al. Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-β in Lewis rats. J. Neuroimmunol. 2004, 156(1–2), 3–9.
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