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3PO
Axon 2175
CAS:
18550-98-6
Purity:
99%
- Soluble in DMSO
- MF: C13H10N2O
- MW: 210.23
Description
Inhibitor of HIF-1-induced PFKFB3, an enzyme with a key role in glycolysis. Potential application as suppressor of tumor glucose metabolism and growth of non-small cell lung cancer cells. The PFKFB3 family member has the highest kinase:bisphosphatase ratio (740:1) of the four known PFKFB family members. 3PO markedly attenuated the stimulation of F2,6BP synthesis, 2-[1-14C]-deoxy-D-glucose uptake, lactate secretion, TNF-α secretion and T cell aggregation and proliferation.
More Information
| Parent CAS No. | 18550-98-6 |
|---|---|
| Chemical Name | (E)-3-(pyridin-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one |
| SMILES | C(C1C=CN=CC=1)(=O)/C=C/C1=CC=CN=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C13H10N2O/c16-13(12-5-8-14-9-6-12)4-3-11-2-1-7-15-10-11/h1-10H/b4-3+ |
| InChiKey | UOWGYMNWMDNSTL-ONEGZZNKSA-N |
| CID | 5720233 |
| Short Description | PFKFB3 inhibitor |
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