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RUSKI-201 dihydrochloride
Axon 2673
- Parent CAS: 1458031-48-5
Purity:
98%
- Soluble in water and DMSO
- MF: C20H27N3OS.2HCl
- MW: 430.43
Description
Sonic Hedgehog acyltransferase (HHAT) inhibitor (IC50 value 0.20 μM) showing no off-target cytotoxicity, and quantitative whole-proteome palmitoylation profiling with a bioorthogonal alkyne-palmitate reporter. RUSKI-201 is the optimal tool molecule currently available to study HHAT function.
More Information
| Parent CAS No. | 1458031-48-5 |
|---|---|
| Chemical Name | 2-(2-methylbutylamino)-1-(4-(6-methylpyridin-2-yl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone dihydrochloride |
| SMILES | C12C=CSC=1CCN(C(=O)CNCC(C)CC)C2C1C=CC=C(C)N=1.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C20H27N3OS.2ClH/c1-4-14(2)12-21-13-19(24)23-10-8-18-16(9-11-25-18)20(23)17-7-5-6-15(3)22-17;;/h5-7,9,11,14,20-21H,4,8,10,12-13H2,1-3H3;2*1H |
| InChiKey | TUDOZEOETHEGCR-UHFFFAOYSA-N |
| CID | 126480616 |
| Short Description | HHAT inhibitor |
References
- UR Rodgers et al. Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells. ACS Chem Biol. 2016 Dec 16;11(12):3256-3262.
- X Zhang et al. Development of anticancer agents targeting the Hedgehog signaling. Cell Mol Life Sci. 2017 Mar 17.
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