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MK-8617
- Soluble in DMSO
- MF: C24H21N5O4
- MW: 443.45
Description
MK-8617 is a potent, orally active pan-inhibitor of HIF-PHD with IC50 values of 1 nM, 1 nM, and 14 nM for PHD1, PHD2 and PHD3, respectively. MK-8617 advanced to human clinical studies as an oral treatment for anemia.
More Information
| Parent CAS No. | 1187990-87-9 |
|---|---|
| Chemical Name | N-(Bis(4-methoxyphenyl)methyl)-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide |
| SMILES | N1N=C(C2=NC(O)=C(C(=O)NC(C3C=CC(OC)=CC=3)C3C=CC(OC)=CC=3)C=N2)C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C24H21N5O4/c1-32-17-9-5-15(6-10-17)21(16-7-11-18(33-2)12-8-16)27-23(30)19-14-25-22(28-24(19)31)20-4-3-13-26-29-20/h3-14,21H,1-2H3,(H,27,30)(H,25,28,31) |
| InChiKey | WXLPERVDMILVIF-UHFFFAOYSA-N |
| CID | 44230662 |
| Short Description | PHD inhibitor |
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