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Daglutril
- SLV 306
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C31H38N2O6
- MW: 534.64
Description
More Information
| Parent CAS No. | 182821-27-8 |
|---|---|
| Chemical Name | 2-((S)-3-(1-((R)-2-(ethoxycarbonyl)-4-phenylbutyl)cyclopentanecarboxamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid |
| SMILES | CCOC(=O)[C@H](CCC1C=CC=CC=1)CC1(CCCC1)C(=O)N[C@H]1CCC2C=CC=CC=2N(CC(O)=O)C1=O |&1:5,23,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C31H38N2O6/c1-2-39-29(37)24(15-14-22-10-4-3-5-11-22)20-31(18-8-9-19-31)30(38)32-25-17-16-23-12-6-7-13-26(23)33(28(25)36)21-27(34)35/h3-7,10-13,24-25H,2,8-9,14-21H2,1H3,(H,32,38)(H,34,35)/t24-,25+/m1/s1 |
| InChiKey | XMQODGUTLZXUGZ-RPBOFIJWSA-N |
| CID | 3038505 |
| Short Description | Dual ECE/NEP inhibitor |
References
- C. Thöne-Reinke et al. Inhibition of both neutral endopeptidase and endothelin-converting enzyme by SLV306 reduces proteinuria and urinary albumin excretion in diabetic rats. J. Cardiovasc. Pharmacol. 2004, 44, S76-79.
- K. Dickstein et al. Effect of single doses of SLV306, an inhibitor of both neutral endopeptidase and endothelin-converting enzyme, on pulmonary pressures in congestive heart failure. Am. J. Cardiol. 2004, 94, 237-239.
- R. Tabrizchi. SLV-306. Solvay. Curr. Opin. Investig. Drugs. 2003, 4, 329-332.
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