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AM 36 dihydrochloride
- CNSB002
- Moderately soluble in water
- MF: C27H39ClN2O2.2HCl
- MW: 531.99
Description
Na+ channel blocker; neuroprotective agent.
More Information
| Parent CAS No. | 199467-52-2 |
|---|---|
| Chemical Name | 2,6-Di-tert-butyl-4-{4-[2-(4-chloro-phenyl)-2-hydroxy-ethyl]-piperazin-1-ylmethyl}-phenol dihydrochloride |
| SMILES | C1(C(C)(C)C)C=C(CN2CCN(CC(O)C3C=CC(Cl)=CC=3)CC2)C=C(C(C)(C)C)C=1O.Cl.Cl |
| MFCD | MFCD10565919 |
| InChi | InChI=1S/C27H39ClN2O2.2ClH/c1-26(2,3)22-15-19(16-23(25(22)32)27(4,5)6)17-29-11-13-30(14-12-29)18-24(31)20-7-9-21(28)10-8-20;;/h7-10,15-16,24,31-32H,11-14,17-18H2,1-6H3;2*1H |
| InChiKey | WDXVQKZIZUKBOZ-UHFFFAOYSA-N |
| CID | 56972138 |
| Short Description | Na+ channel Blocker |
References
- J. K. Callaway et al. Delayed Treatment With AM-36, a Novel Neuroprotective Agent, Reduces Neuronal Damage After Endothelin-1–Induced Middle Cerebral Artery Occlusion in Conscious Rats. Stroke. 1999, 30, 2704-2712.
- J. K Callaway et al. Incorporation of sodium channel blocking and free radical scavenging activities into a single drug, AM-36, results in profound inhibition of neuronal apoptosis. Br. J. Pharmacol. 2001, 132, 1691–1698.
- A. Kolosov et al. Studies of synergy between morphine and a novel sodium channel blocker, CNSB002, in rat models of inflammatory and neuropathic pain. Pain Med. 2010 Jan;11(1):106-18.
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