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Adjudin
- AF 2364
- Soluble in DMSO
- MF: C15H12Cl2N4O
- MW: 335.19
Description
Non-hormonal male contraceptive that exerts its effect by disrupting Sertoli-germ cell adhesion junctions, most notably apical ectoplasmic specialization (apical ES), by targeting testin and actin filament bundles that disrupt the actin-based cytoskeleton in Sertoli cells. Adjudin is a potent blocker of Cl- channels. Moreover, Adjudin is shown to induce apoptosis in cancer cells through a Caspase-3-dependent pathway, and triggers mitochondrial dysfunction in cancer cells, apparently affecting the mitochondrial mass, inducing the loss of mitochondrial membrane potential and reducing cellular ATP levels. Furthermore, Adjudin posesses anti-inflammation, anti-neurodegeneration, and anti-ototoxicity activities based on studies using different in vitro and in vivo models.
More Information
| Parent CAS No. | 252025-52-8 |
|---|---|
| Chemical Name | 1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide |
| SMILES | N1(CC2=CC=C(Cl)C=C2Cl)C2=C(C=CC=C2)C(C(NN)=O)=N1 |
| MFCD | N.A. |
| InChi | InChI=1S/C15H12Cl2N4O/c16-10-6-5-9(12(17)7-10)8-21-13-4-2-1-3-11(13)14(20-21)15(22)19-18/h1-7H,8,18H2,(H,19,22) |
| InChiKey | VENCPJAAXKBIJD-UHFFFAOYSA-N |
| CID | 9819086 |
| Short Description | Male contraceptive |
References
- CY Cheng et al. Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis. Biol Reprod. 2001 Aug;65(2):449-61.
- QR Xie et al. Male contraceptive Adjudin is a potential anti-cancer drug. Biochem Pharmacol. 2013 Feb 1;85(3):345-55.
- K Li et al. Inhibition of sperm capacitation and fertilizing capacity by adjudin is mediated by chloride and its channels in humans. Hum Reprod. 2013 Jan;28(1):47-59.
- YH Cheng et al. Adjudin - A Male Contraceptive with Other Biological Activities. Recent Pat Endocr Metab Immune Drug Discov. 2015;9(2):63-73.
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