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ML 367
- CID 921541
- Soluble in DMSO
- MF: C19H12F2N4
- MW: 334.32
Description
ML 367 is an inhibitor of ATAD5 stabilization with an IC50 value of 1.2 μM. ML 367 was found to block general DNA damage responses including RPA32-hosphorylation and CHK1-phosphorylation in response to UV irradiation. In this regard, the probe molecule could block DNA repair pathways that function upstream of ATAD5.
More Information
| Parent CAS No. | 381168-77-0 |
|---|---|
| Chemical Name | N-(3,4-Difluorophenyl)-2-(pyridin-4-yl)quinazolin-4-amine |
| SMILES | C1C2C(NC3C=C(F)C(F)=CC=3)=NC(C3C=CN=CC=3)=NC=2C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H12F2N4/c20-15-6-5-13(11-16(15)21)23-19-14-3-1-2-4-17(14)24-18(25-19)12-7-9-22-10-8-12/h1-11H,(H,23,24,25) |
| InChiKey | LBPYNNJXARHGAG-UHFFFAOYSA-N |
| CID | 921541 |
| Short Description | ATAD5 inhibitor |
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