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PNU 22394 hydrochloride
- Parent CAS: 15923-78-1
- Soluble in DMSO
- MF: C13H16N2.HCl
- MW: 236.74
Description
Potent 5-HT2 ligand (Ki values 18 nM, 18 nM, and 66 nM for 5-HT2A, 5-HT2C, and 5-HT2B, respectively). PNU 22394 is virtually a full agonist at 5-HT2C receptors (87% of 5-HT), but a partial agonist at 5-HT2A (65% of 5-HT), and 5-HT2B (<15% of 5-HT) receptors, and produced a dose-related decrease in food consumption compared to saline-treated control rats.
More Information
| Parent CAS No. | 15923-78-1 |
|---|---|
| Chemical Name | 6-Methyl-1,2,3,4,5,6-hexahydro-azepino[4,5-b]indole hydrochloride |
| SMILES | C1=CC=CC2C3CCNCCC=3N(C)C1=2.Cl |
| MFCD | MFCD01665206 |
| InChi | InChI=1S/C13H16N2.ClH/c1-15-12-5-3-2-4-10(12)11-6-8-14-9-7-13(11)15;/h2-5,14H,6-9H2,1H3;1H |
| InChiKey | SAIGGEUWSYESTR-UHFFFAOYSA-N |
| CID | 16759162 |
| Short Description | 5-HT2C agonist |
References
- Dunlop, j. et al. WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor-selective agonist with anorectic activity. J. Pharmacol. Exp. Ther. 2005, 313(2), 862-869.
- Bishop, M.J. et al. New 5-HT2C receptor agonists Expert Opin. Ther. Patents 2003, 13 (11), 1691-1705.
- RB McCall et al. PNU-22394, a 5-HT2C receptor agonist, reduces feeding in rodents and produces weight loss in humans. Neuroscience 2001 Abstract, Presentation Number: 309.2
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