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NSC 228155
- Soluble in DMSO
- MF: C11H6N4O4S
- MW: 290.25
Description
EGFR activator. Furthermore, NSC 228155 was identified as a potent inhibitor of KIX-KID interaction with an IC50 value of 0.36 µM.
More Information
| Parent CAS No. | 113104-25-9 |
|---|---|
| Chemical Name | 2-(7-Nitrobenzo[c][1,2,5]oxadiazol-4-ylthio)pyridine 1-oxide |
| SMILES | C1=C(SC2[N+]([O-])=CC=CC=2)C2=NON=C2C([N+]([O-])=O)=C1 |
| MFCD | MFCD30742994 |
| InChi | InChI=1S/C11H6N4O4S/c16-14-6-2-1-3-9(14)20-8-5-4-7(15(17)18)10-11(8)13-19-12-10/h1-6H |
| InChiKey | ICCFXXDUYSPKOL-UHFFFAOYSA-N |
| CID | 313619 |
| Short Description | EGFR activator |
References
- F Xie et al. Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5371-5.
- V Sakanyan et al. Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells. Sci Rep. 2014 Feb 5;4:3977.
- Sakanyan V, et al. Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1. Sci Rep. 2016 Feb 17;6:21088.
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