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Tenilsetam
- PAS 997 - CAS 997 - HR 029
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C8H10N2OS
- MW: 182.24
Description
Endonuclease modulator; a nootropic agent and advanced glycation end product (AGE) inhibitor having potential for Alzheimer's disease (AD) treatment.
Preclinical studies on diabetic rats suggested that tenilsetam may be beneficial in the inhibition of diabetic retinopathy, without amelioration of pericyte loss
More Information
| Parent CAS No. | 86696-86-8 |
|---|---|
| Chemical Name | 3-Thiophen-2-yl-piperazin-2-one |
| SMILES | C1NC(=O)C(C2SC=CC=2)NC1 |
| MFCD | MFCD00867779 |
| InChi | InChI=1S/C8H10N2OS/c11-8-7(9-3-4-10-8)6-2-1-5-12-6/h1-2,5,7,9H,3-4H2,(H,10,11) |
| InChiKey | BBACKDMGYMXYLE-UHFFFAOYSA-N |
| CID | 65649 |
| Short Description | AGE inhibitor |
References
- G Munch et al. The cognition-enhancing drug tenilsetam is an inhibitor of protein crosslinking by advance glycosylation. J. Neural. Transm. Sect. 1994, 8(3), 193-208.
- TJ Roesler et al. Advanced glycation end product (AGE) inhibition as a possible pharmacotherapeutic strategy in the treatment of Alzheimer's disease. Drugs Fut. 1999, 24(4), 411.
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