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LP-935509
- Soluble in DMSO
- MF: C20H24N6O3
- MW: 396.44
Description
Potent, brain penetrant inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50 value 3.3 nM and 14 nM and 320 nM for the closely related BIKE and GAK enzymes, repsectively). LP-935509 is antinociceptive in multiple rat models of neuropathic pain, but not acute pain. The AAK1 inhibitor-induced antinociception and inhibition of spontaneous neural activity can be blocked by α2 adrenergic antagonists.
More Information
| Parent CAS No. | 1454555-29-3 |
|---|---|
| Chemical Name | isopropyl 4-(3-(2-methoxypyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate |
| SMILES | N1(C(OC(C)C)=O)CCN(C2C=CN3N=CC(C4=CC=CN=C4OC)=C3N=2)CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C20H24N6O3/c1-14(2)29-20(27)25-11-9-24(10-12-25)17-6-8-26-18(23-17)16(13-22-26)15-5-4-7-21-19(15)28-3/h4-8,13-14H,9-12H2,1-3H3 |
| InChiKey | GOOYSJIWTIHOGW-UHFFFAOYSA-N |
| CID | 86697436 |
| Short Description | AAK1 inhibitor |
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