TNG-260
- Optical Purity: 98% e.e.
- Soluble in DMSO
- MF: C20H18FN3O2S
- MW: 383.44
Description
TNG-260 is a first-in-class, orally active, potent, and CoREST-selective deacetylase inhibitor. It inhibits HDAC1 with 10-fold selectivity over HDAC3 in cells, and 500-fold selectivity for the CoREST complex over the other HDAC1-containing complexes, NuRD and Sin3. TNG-260 reverses the immune evasion phenotype caused by loss of STK11 and induces tumor regressions in an STK11-mutant model in combination with α-PD1.
More Information
| Parent CAS No. | 2935964-98-8 |
|---|---|
| Chemical Name | (R)-N-(4-Amino-4'-fluorobiphenyl-3-yl)-4-(S-methylsulfonimidoyl)benzamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(NC(=O)C2C=CC([S@@](C)(=O)=N)=CC=2)C(N)=CC=C(C2C=CC(F)=CC=2)C=1 |&1:8,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | CoREST-selective deacetylase inhibitor |
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