Tubacin
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C41H43N3O7S
- MW: 721.86
Description
Tubacin is a specific inhibitor of HDAC6, one of 11 known human HDACs. Besides deacetylating tubulin, HDAC6 binds both polyubiquinated proteins (i.e., proteins marked for degradation by attached ubiquitin "flags") and dynein (a protein motor associated with microtubules), bringing the two together to help the cell clean house. This takes place through a recently described cell structure called the aggresome. There is growing evidence to support the relevance of HDAC6 and its non-histone substrates as a target for other cancers, including breast cancer. In addition, HDAC6 also targets another cellular protein known as Hsp90, a protein critical in helping other proteins achieve their correct conformation, including proteins implicated in many forms of cancer.
More Information
| Parent CAS No. | 537049-40-4 |
|---|---|
| Chemical Name | N1-(4-((2R,4R,6S)-4-((4,5-diphenyloxazol-2-ylthio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxyoctanediamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | O1[C@@H](CSC2=NC(C3C=CC=CC=3)=C(C3C=CC=CC=3)O2)C[C@@H](C2C=CC(CO)=CC=2)O[C@H]1C1C=CC(NC(=O)CCCCCCC(=O)NO)=CC=1 |&1:1,22,32,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H,44,47)/t34-,35+,40+/m1/s1 |
| InChiKey | BHUZLJOUHMBZQY-YXQOSMAKSA-N |
| CID | 6675804 |
| Short Description | HDAC6 inhibitor |
References
- S. Barua et al. The influence of mediators of intracellular trafficking on transgene expression efficacy of polymer-plasmid DNA complexes. Biomaterials 2010, 31, 5894-5902.
- J. Hong et al. A new approach to tubacin. Letters in Organic Chemistry (2010), 7, 50-53.
- J. Bradner et al. Chemical phylogenetics of histone deacetylases. Nature Chemical Biology 2010, 6, 238-243.
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