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UNC6934
- Soluble in DMSO
- MF: C24H21N5O4
- MW: 443.45
Description
UNC6934 is a potent and selective chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2 (Kd value of 91 nM). Moreover, UNC6934 disrupted the interaction between NSD2-PWWP1 and nucleosomal H3K36me2 in a dose-dependent manner with an IC50 value of 104 nM. The negative control UNC7145 is also available as Axon 3592.
More Information
| Parent CAS No. | 2561494-77-5 |
|---|---|
| Chemical Name | N-Cyclopropyl-3-oxo-N-(4-(pyrimidin-4-ylcarbamoyl)benzyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide |
| SMILES | C12OCC(=O)NC=1C=CC(C(=O)N(C1CC1)CC1C=CC(C(=O)NC3N=CN=CC=3)=CC=1)=C2 |
| MFCD | N.A. |
| InChi | InChI=1S/C24H21N5O4/c30-22-13-33-20-11-17(5-8-19(20)27-22)24(32)29(18-6-7-18)12-15-1-3-16(4-2-15)23(31)28-21-9-10-25-14-26-21/h1-5,8-11,14,18H,6-7,12-13H2,(H,27,30)(H,25,26,28,31) |
| InChiKey | KOZGEDUWAQFVAV-UHFFFAOYSA-N |
| CID | 146676966 |
| Short Description | NSD2-PWWP1 antagonist |
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