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UNC8732
Axon 4245
CAS:
2929304-05-0
Purity:
98%
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C35H39N5O5
- MW: 609.71
Description
UNC8732 is a second-generation NSD2 degrader (DC50 value of 60 nM; Dmax of 97%) that demonstrates improved NSD2 degradation and H3K36me2 reduction in cells. UNC8732 contains a primary alkyl amine, which is metabolized in cells to an active aldehyde species that promotes NSD2 degradation through the recruitment of FBXO22, a substrate recognition subunit of a Cullin 1 E3 ligase complex.
More Information
| Parent CAS No. | 2929304-05-0 |
|---|---|
| Chemical Name | N-(4-(2-(6-Aminohexanoyl)-1,2,3,4-tetrahydroisoquinolin-6-ylcarbamoyl)benzyl)-N-cyclopropyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide |
| MFCD | N.A. |
| Short Description | NSD2 degrader |
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