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Veliparib dihydrochloride
- ABT-888 dihydrochloride
- Parent CAS: 912444-00-9
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C13H1N4O.2HCl
- MW: 317.21
Description
Potent and orally bioavailable PARP inhibitor, with Ki values to be 5.2 nM for PARP1 and 2.9 nM for PARP2 respectively; inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents.
The free base of ABT 888 is available as Axon 1593.
More Information
| Parent CAS No. | 912444-00-9 |
|---|---|
| Chemical Name | (R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide dihydrochloride |
| SMILES | C1C(C(N)=O)=C2N=C([C@@]3(C)CCCN3)NC2=CC=1.Cl.Cl |&1:8,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C13H16N4O.2ClH/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12;;/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17);2*1H/t13-;;/m1../s1 |
| InChiKey | DSBSVDCHFMEYBX-FFXKMJQXSA-N |
| CID | 45480520 |
| Short Description | PARP inhibitor |
References
- CK Donawho et al. ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models. Clin. Cancer Res. 2007, 13, 2728.
- P Palma et al. The PARP inhibitor, ABT-888 potentiates temozolomide: correlation with drug levels and reduction in PARP activity in vivo. Anticancer Res. 2008, 28(5A), 2625-2635.
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