Bulk Inquiry
ITD 1
- Soluble in DMSO
- MF: C27H29NO3
- MW: 415.52
Description
Selective inhibitor of TGFβ/Smad signaling (IC50 value 0.85 μM; 83% TGF-β inhibiton at 2.5 μM) that acts by clearing the type II TGFβ receptor from the cell surface. ITD1 stimulates the differentiation of cardiomyocytes and promote cardiogenesis in murine embryonic stem cell (mESCs). TGFβ inhibition by the (+)-eneatiomer is approximately 15-fold more effective than by its (−)-enantiomer.
Note: The optically pure (+)-ITD 1 (Axon 2467) is available as well
More Information
| Parent CAS No. | 1099644-42-4 |
|---|---|
| Chemical Name | ethyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate |
| SMILES | N1C2=C(C(=O)CC(C)(C)C2)C(C2=CC=C(C3=CC=CC=C3)C=C2)C(C(OCC)=O)=C1C |w:10,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C27H29NO3/c1-5-31-26(30)23-17(2)28-21-15-27(3,4)16-22(29)25(21)24(23)20-13-11-19(12-14-20)18-9-7-6-8-10-18/h6-14,24,28H,5,15-16H2,1-4H3 |
| InChiKey | ULFUJLFTRWWLPO-UHFFFAOYSA-N |
| CID | 44135961 |
| Short Description | TGF-βR2 inhibitor |
References
- D. Schade et al. Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling. J. Med. Chem. 2012, 55, 9946-9957.
- E. Willems et al. Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012, 11, 242-252.
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