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AMD 3100
- Plerixafor - SID 791 - JM 3100
- Parent CAS: 110078-46-1
- Soluble in water
- MF: C28H54N8.8HCl
- MW: 794.47
Description
More Information
| Parent CAS No. | 110078-46-1 |
|---|---|
| Chemical Name | 1,4-bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene octahydrochloride |
| SMILES | Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl.N1CCNCCCN(CC2C=CC(CN3CCNCCCNCCNCCC3)=CC=2)CCNCCC1 |
| MFCD | MFCD04974488 |
| InChi | InChI=1S/C28H54N8.8ClH/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H |
| InChiKey | UEUPDYPUTTUXLJ-UHFFFAOYSA-N |
| CID | 65014 |
| Short Description | CXCR4 antagonist |
References
- E De Clercq et al. Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100. Antimicrob. agents chemother. 1994, 38(4), 668–74.
- SL Davies et al. Plerixafor Hydrochloride. Drugs Fut. 2007, 32(2), 123.
- AF Cashen et al. AMD3100: CXCR4 antagonist and rapid stem cell-mobilizing agent. Future Oncol. 2007, 3(1), 19–27.
- G Calandra et al. AMD3100 plus G-CSF can successfully mobilize CD34+ cells from non-Hodgkin's lymphoma, Hodgkin's disease and multiple myeloma patients previously failing mobilization with chemotherapy (...). Bone Marrow Transpl. 2008, 41, 331–338.
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