Rucaparib camsylate

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3113

CAS [1859053-21-6]

MF C19H18FN3O.C10H16O4S
MW 555.66

Purity: 99%
Soluble in DMSO

Rucaparib camsylate

Description

A PARP 1 inhibitor with potential chemosensitizing, radiosensitizing and antineoplastic activities; selectively binds to PARP1 (Ki=1.4 nM) and inhibits PARP1-mediated DNA repair, thereby enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. Also available as the phosphate salt AG 014699 (Axon 1529).

HD Thomas et al. Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol. Cancer Ther. 2007, 6(3), 945-56.

P Plummer et al. Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors. Clin Cancer Res. 2008, 14(23), 7917-23.

M Ali et al. Vasoactivity of AG014699, a Clinically Active Small Molecule Inhibitor of Poly(ADP-ribose) Polymerase: a Contributory Factor to Chemopotentiation In vivo? Clin. Cancer Res. 2009, 15(19), 6106-6112.

PARP1 inhibitor

Chemical name

8-Fluoro-5-(4-((methylamino)methyl)phenyl)-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one ((1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate

Parent CAS No.

[283173-50-2]

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Size	Unit Price	Stock
10 mg	€90.00	In Stock
50 mg	€270.00	In Stock

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Rucaparib camsylate

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Description

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