Veliparib dihydrochloride - ABT-888 dihydrochloride

Based on 8 reference(s) in Google Scholar 8 10 8

Axon 2888

CAS [912445-05-7]

MF C13H1N4O.2HCl
MW 317.21

Purity: 99%
Optical purity: Optically pure
Soluble in water and DMSO

Veliparib dihydrochloride

Description

Potent and orally bioavailable PARP inhibitor, with Ki values to be 5.2 nM for PARP1 and 2.9 nM for PARP2 respectively; inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents.

The free base of ABT 888 is available as Axon 1593.

Keywords: Veliparib dihydrochloride | Supplier | PARP inhibitor | ABT-888 dihydrochloride | A861695 | A-861695 | A 861695 | ABT888 | ABT 888 | CAS [912445-05-7] | [912444-00-9] | DNA-RNA | PARP | Inhibitor | Enzymes

CK Donawho et al. ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models. Clin. Cancer Res. 2007, 13, 2728.

P Palma et al. The PARP inhibitor, ABT-888 potentiates temozolomide: correlation with drug levels and reduction in PARP activity in vivo. Anticancer Res. 2008, 28(5A), 2625-2635.

PARP inhibitor

Chemical name

(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide dihydrochloride

Parent CAS No.

[912444-00-9]

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Size	Unit Price	Stock
10 mg	€95.00	In Stock
50 mg	€285.00	In Stock

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Size	Unit Price	Stock
2 x 10 mg	€140.00	In Stock
2 x 50 mg	€420.00	In Stock

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Veliparib dihydrochloride - ABT-888 dihydrochloride

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Veliparib dihydrochloride - ABT-888 dihydrochloride

Description

Chemical name

Parent CAS No.

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