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Tacrolimus - FK 506

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2263

CAS [104987-11-3]

MF C44H69NO12
MW 804.02

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO

Tacrolimus

Description

Potent Calcineurin inhibitor (calcium dependent serine/threonine protein phosphatase 2B). The mechanism of action of FK 506 (Tacrolimus) involves the formation of a molecular complex with the the immunophilin FKBP12 (IC50 value 3 nM), to reduce its peptidyl-prolyl isomerase activity. Tacrolimus potently inhibits T-cell activation-induced TNF-α, IL-1β, IL-2, IL-3, IL-4, and IL-6 production, but does not affect LPS-induced cytokine production and proliferation of normal cells, such as bone marrow cells. Immunosuppressant, neuroprotectant and anticonvulsant.
Potent Calcineurin (Ca2+ dependent protein phosphatase 2B) inhibitor

Chemical name

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-e

Parent CAS No.

[104987-11-3]

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10 mg €100.00 In Stock
50 mg €380.00 In Stock
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2 x 10 mg €160.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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