Sephin 1 - NSC 65390

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2524

CAS [951441-04-6]

MW 196.64

  • Purity: 99%
  • Soluble in DMSO

Sephin 1


Selective PPP1R15A inhibitor devoid of PPP1R15B and α2-adrenergic activity. In cells, Sephin1 selectively disrupted the PPP1R15A-PP1c complex, therebye prolonging eIF2α phosphorylation after stress, delaying translation recovery, and consequently, attenuated expression of stress genes such as the pro-apoptotic protein CHOP. The cytoprotectant prevents protein misfolding, motor deficits, motor neuron loss, and the molecular defects in SOD1 mutant mice.

KEYWORDS: Sephin 1 |  supplier| | PPP1R15A inhibitor | NSC 65390 | Sephin 1 | NSC65390 | CAS [951441-04-6]-[951345-60-1]-[13098-73-2] | PPP1R15A | Inhibitor | phosphatase | cytoprotectant | protein | misfolding | Charcot-Marie-Tooth 1B | CMT1B

Size Unit Price Stock
10 mg €55.00 In Stock
50 mg €195.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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