Selective PPP1R15A inhibitor devoid of PPP1R15B and α2-adrenergic activity. In cells, Sephin1 selectively disrupted the PPP1R15A-PP1c complex, therebye prolonging eIF2α phosphorylation after stress, delaying translation recovery, and consequently, attenuated expression of stress genes such as the pro-apoptotic protein CHOP. The cytoprotectant prevents protein misfolding, motor deficits, motor neuron loss, and the molecular defects in SOD1 mutant mice.

KEYWORDS: Sephin 1 |  supplier| | PPP1R15A inhibitor | NSC 65390 | Sephin 1 | NSC65390 | CAS [951441-04-6]-[951345-60-1]-[13098-73-2] | PPP1R15A | Inhibitor | phosphatase | cytoprotectant | protein | misfolding | Charcot-Marie-Tooth 1B | CMT1B