INCB 024360-analog - IDO inhibitor 5l

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2215

CAS [914471-09-3]

MF C9H7ClFN5O2
MW 271.64

Purity: 99%
Soluble in DMSO

INCB 024360-analog

Description

Potent competitive inhibitor of indoleamine 2,3-dioxygenase (IDO1, IC50 value 67 nM) with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model; This INCB024360-analog decreased kynurenine levels by >50% in plasma and inhibited B16-GM-CSF tumor growth in a dose dependent fashion.

INCB 024360 (or Epacadostat; Axon 1733) is available from Axon Medchem as well.

E.W. Yue et al. Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J. Med. Chem. 2009, 52, 7364-7367.

X. Liu et al. Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood 2010, 115, 3520-3530.

X. Huang et al. Synthesis of [(18) F] 4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide (IDO5L): a novel potential PET probe for imaging of IDO1 expression. J Labelled Comp Radiopharm. 2015 Apr;58(4):156-62.

Potent inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1)

Chemical name

4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Parent CAS No.

[914471-09-3]

Order

Size	Unit Price	Stock
5 mg	€85.00	In Stock
25 mg	€255.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	€120.00	In Stock
2 x 25 mg	€360.00	In Stock

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INCB 024360-analog - IDO inhibitor 5l

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INCB 024360-analog - IDO inhibitor 5l

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