Based on 2 reference(s) in Google Scholar 8 10 2

Axon 3967

CAS [2166616-75-5]

MF C23H25FN2O3
MW 396.45

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO



LY-3381916 is an orally available, potent and selective inhibitor of indoleamine 2,3-dioxygenase 1 (IDO-1) (IC50 = 7 nM on Cell-based, newly synthesized IDO-1 lacking heme), with potential immunomodulating and antineoplastic activities. Upon administration, IDO1 inhibitor LY3381916 specifically targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the amino acid tryptophan into the immunosuppressive metabolite kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, LY3381916 restores and promotes the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T lymphocytes, and causes a reduction in tumor-associated regulatory T cells (Tregs). Activation of the immune system, which is suppressed in many cancers, may induce a cytotoxic T-lymphocyte (CTL) response against the IDO1-expressing tumor cells, thereby inhibiting the growth of IDO1-expressing tumor cells. IDO1, overexpressed by multiple tumor cell types, plays an important role in immunosuppression. Tryptophan depletion inhibits T-lymphocyte proliferation and activation, and subsequently suppresses the immune system.

KEYWORDS: LY-3381916 | Supplier | IDO1 inhibitor | LY3381916 | LY 3381916 | CT-LY3381 | CAS [2166616-75-5] | L-Kynurenine | IDO1 | Inhibitor | Enzymes

Potent and selective inhibitor of indoleamine 2,3-dioxygenase 1 (IDO-1)

Chemical name


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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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