INCB 024360 - Epacadostat

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1733

CAS [1204669-58-8]

MF C11H13BrFN7O4S
MW 438.23

Purity: 98%
Soluble in DMSO

INCB 024360

Description

Potent competitive inhibitor of indoleamine 2,3-dioxygenase (IDO1, IC50 value 72 nM in vitro) with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model; INCB024360 (Epacadostat) decreased kynurenine levels by >50% in plasma and inhibited B16-GM-CSF tumor growth in a dose dependent fashion.

An analog of INCB 024360 (Axon 2215) is available as well.

C. Sheridan. IDO inhibitors move center stage in immuno-oncology. Nat Biotechnol. 2015 Apr;33(4):321-2.

U.F. Röhrig et al. Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors. J Med Chem. 2015 May 26.

X. Liu et al. Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood. 2010 Apr 29;115(17):3520-30.

Apoptosis Cell Signaling & Oncology CNS Immunology Pain & Inflammation IDO1 EC 1.13.11.52

Potent inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1)

Chemical name

(Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-(2-(sulfamoylamino)ethylamino)-1,2,5-oxadiazole-3-carboximidamide

Parent CAS No.

[1204669-58-8]

Order

Size	Unit Price	Stock
5 mg	€90.00	In Stock
25 mg	€310.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	€140.00	In Stock
2 x 25 mg	€480.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
2118	UPF 648	Potent inhibitor of kynurenine-3-monooxygenase (KMO)	€110.00
2139	RO 61-8048	Inhibitor of kynurenine-3-monooxygenase (KMO)	€95.00
2215	INCB 024360-analog	Potent inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1)	€85.00
2337	XCT 790	ERRα inverse agonist and potent mitochondrial uncoupler	€120.00
2489	Brassinin	Dual IDO1/STAT3 inhibitor with antifungal and anticancer activity	€75.00
3325	PF-06840003	Selective, brain penetrant, and orally bioavailable IDO1 inhibitor	€70.00
3967	LY-3381916	Potent and selective inhibitor of indoleamine 2,3-dioxygenase 1 (IDO-1)	Inquire

Customer Support

Customer Services

About Axon Medchem

Contact Us

INCB 024360 - Epacadostat

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

INCB 024360 - Epacadostat

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us