PF-06840003 - EOS200271

Based on 38 reference(s) in Google Scholar 8 10 38

Axon 3325

CAS [198474-05-4]

MF C12H9FN2O2
MW 232.21

  • Purity: 98%
  • Soluble in 0.1N NaOH(aq) and DMSO

PF-06840003

Description

PF-06840003 is a selective, brain penetrant, and orally bioavailable IDO-1 inhibitor. Although PF-06840003 has moderate hIDO1 enzyme inhibition (IC50 value of 0.41 μM), it is a highly efficient compound (LE 0.53, LipE 5.1), driven by its tight packing within the enzyme, as well as the high density of hydrogen bonds it forms with hIDO-1 despite its small size.

KEYWORDS: PF-06840003 | supplier | IDO1 inhibitor | EOS200271 | PF 06840003 | PF06840003 | EOS 200271 | EOS-200271' | CAS [198474-05-4] | Kynurenine |  L- | IDO1 | Inhibitor | Enzymes | Immunotherapy

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Size Unit Price Stock
10 mg €70.00 In Stock
50 mg €170.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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