PF-06840003 is a selective, brain penetrant, and orally bioavailable IDO-1 inhibitor. Although PF-06840003 has moderate hIDO1 enzyme inhibition (IC50 value of 0.41 μM), it is a highly efficient compound (LE 0.53, LipE 5.1), driven by its tight packing within the enzyme, as well as the high density of hydrogen bonds it forms with hIDO-1 despite its small size.

KEYWORDS: PF-06840003 | supplier | IDO1 inhibitor | EOS200271 | PF 06840003 | PF06840003 | EOS 200271 | EOS-200271' | CAS [198474-05-4] | Kynurenine |  L- | IDO1 | Inhibitor | Enzymes | Immunotherapy