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Axon 4248
CAS [N.A.]
MF C22H13Cl2F3N4O2MW 493.27
SC912 is an AR-V7 inhibitor which binds to full-length AR as well as AR-V7 through AR N-terminal domain (AR-NTD). SC912 also disrupted AR-V7 transcriptional activity, impaired AR-V7 nuclear localization and DNA binding. In the AR-V7 positive CRPC cells, SC912 suppressed proliferation, induced cell-cycle arrest, and apoptosis. In the AR-V7 expressing CRPC xenografts, SC912 attenuated tumor growth and antagonized intratumoral AR signaling.
KEYWORDS: SC912 | Supplier | AR-V7 inhibitor | SC 912 | SC-912 | CAS [N.A.] | | Androgenic hormones | Inhibitor | Androgen deprivation therapy | ADT | Castration-resistant prostate cancer | CRPC
N-{2-[3-(3-Cyanophenyl)urea]-5-(trifluoromethyl)phenyl}-3,5-dichlorobenzamide
[N.A.]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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