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ML162

Based on 29 reference(s) in Google Scholar 8 10 29

Axon 3896

CAS [1035072-16-2]

MF C23H22Cl2N2O3S
MW 477.40

Purity: 98%
Soluble in DMSO and EtOH

ML162

Description

ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor and ferroptosis inducer.

KEYWORDS: ML162 | Supplier | GPX4 inhibitor | ML 162 | ML-162 | CAS [1035072-16-2] | RAS proteins | Ferroptosis | Inhibitor | Proteins | Synthetic lethal | CID3689413

T Luo et al. Intracellular Delivery of Glutathione Peroxidase Degrader Induces Ferroptosis In Vivo. Angew Chem Int Ed Engl. 2022 Sep 26;61(39):e202206277.

M Weïwer et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6.

Apoptosis Cell Signaling & Oncology Ferroptosis

Covalent GPX4 inhibitor; Ferroptosis inducer

Chemical name

2-Chloro-N-(3-chloro-4-methoxyphenyl)-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide

Parent CAS No.

[1035072-16-2]

Order

Size	Unit Price	Stock
10 mg	€90.00	In Stock
50 mg	€300.00	In Stock

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