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PF-06821497
- Mevrometostat
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C22H24Cl2N2O5
- MW: 467.34
Description
PF-06821497 (optically pure R-enantiomer) is a small molecule inhibitor of Histone Methyltransferase (HMT) EZH2, potently and selectively inhibiting the activities of both wild-type (Ki = 0.3nM) and mutant (Y641N) (Ki < 0.1nM).
More Information
| Parent CAS No. | 1844849-10-0 |
|---|---|
| Chemical Name | (R)-5,8-dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1([C@H](OC)C2COC2)C(Cl)=C2C(=O)N(CC3C(=O)NC(C)=CC=3OC)CCC2=C(Cl)C=1 |&1:1,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H24Cl2N2O5/c1-11-6-17(29-2)15(21(27)25-11)8-26-5-4-13-16(23)7-14(19(24)18(13)22(26)28)20(30-3)12-9-31-10-12/h6-7,12,20H,4-5,8-10H2,1-3H3,(H,25,27)/t20-/m1/s1 |
| InChiKey | RXCVUHMIWHRLDF-HXUWFJFHSA-N |
| CID | 118572065 |
| Short Description | EZH2 HMTase inhibitor |
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