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PF-06821497

Based on 8 reference(s) in Google Scholar 8 10 8

Axon 3695

CAS [1844849-10-0]

MF C22H24Cl2N2O5
MW 467.34

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO

PF-06821497

Description

PF-06821497 (optically pure R-enantiomer) is a small molecule inhibitor of Histone Methyltransferase (HMT) EZH2, potently and selectively inhibiting the activities of both wild-type (Ki = 0.3nM) and mutant (Y641N) (Ki < 0.1nM).

KEYWORDS: PF-06821497 | Supplier | EZH2 HMTase inhibitor | PF06821497 | PF 06821497 | CT-PF0682 | CAS [1844849-10-0] | Histone | HMTase | Inhibitor | Enzymes

Inhibitor of Histone Lysine Methyltransferase EZH2

Chemical name

(R)-5,8-dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1844849-10-0]

Related Products

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3469 MS1943 trifluoroacetate First-in-class EZH2 selective degrader; PROTAC €200.00
3722 Valemetostat Inhibitor of Histone Lysine Methyltransferase EZH1/2 Inquire

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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