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LOXO-101 sulfate
- Larotrectinib sulfate - ARRY-470
- Parent CAS: 1223403-58-4
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C21H22F2N6O2.H2SO4
- MW: 526.51
Description
LOXO-101 sulfate is a first-in-class, potent, highly selective and ATP-competitive tropomyosin receptor kinase (TRK) inhibitor with IC50 values of 6.5 nM, 8.1 nM and 10.6 nM for TRKA, TRKB and TRKC, respectively.
More Information
| Parent CAS No. | 1223403-58-4 |
|---|---|
| Chemical Name | (S)-N-(5-((R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide sulfate |
| SMILES | C1=CN2N=CC(NC(=O)N3C[C@@H](O)CC3)=C2N=C1N1CCC[C@@H]1C1C(F)=CC=C(F)C=1.OS(O)(=O)=O |&1:11,22,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C21H22F2N6O2.H2O4S/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27;1-5(2,3)4/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31);(H2,1,2,3,4)/t14-,18+;/m0./s1 |
| InChiKey | PXHANKVTFWSDSG-QLOBERJESA-N |
| CID | 67330085 |
| Short Description | TRK inhibitor |
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