Irinotecan hydrochloride - CPT-11 | Camptothecin 11

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3370

CAS [100286-90-6]

MF C33H38N4O6.HCl
MW 623.14

Purity: 100%
Optical purity: Optically pure
Soluble in DMSO

Irinotecan hydrochloride

Description

Irinotecan hydrochloride is the prodrug for SN-38, which is a topoisomerase I inhibitor. SN-38 has demonstrated potent growth inhibition of human colorectal cancer cells in vitro, with superior activity to fluorouracil.

LR Wiseman et al. Irinotecan. A review of its pharmacological properties and clinical efficacy in the management of advanced colorectal cancer. Drugs. 1996 Oct;52(4):606-23.

FM de Man et al. Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics. Clin Pharmacokinet. 2018 Oct;57(10):1229-1254.

Prodrug of SN-38; Topoisomerase I (Topo 1) inhibitor

Chemical name

[(19S)-10,19-Diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate hydrochloride

Parent CAS No.

[97682-44-5]

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Irinotecan hydrochloride - CPT-11 | Camptothecin 11

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Irinotecan hydrochloride - CPT-11 | Camptothecin 11

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Parent CAS No.

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