Irinotecan hydrochloride - CPT-11 | Camptothecin 11

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3370

CAS [100286-90-6]

MF C33H38N4O6.HCl
MW 623.14

Purity: 100%
Optical purity: Optically pure
Soluble in DMSO

Irinotecan hydrochloride

Description

Irinotecan hydrochloride is the prodrug for SN-38, which is a topoisomerase I inhibitor. SN-38 has demonstrated potent growth inhibition of human colorectal cancer cells in vitro, with superior activity to fluorouracil.

LR Wiseman et al. Irinotecan. A review of its pharmacological properties and clinical efficacy in the management of advanced colorectal cancer. Drugs. 1996 Oct;52(4):606-23.

FM de Man et al. Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics. Clin Pharmacokinet. 2018 Oct;57(10):1229-1254.

Prodrug of SN-38; Topoisomerase I (Topo 1) inhibitor

Chemical name

[(19S)-10,19-Diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate hydrochloride

Parent CAS No.

[97682-44-5]

Order

Size	Unit Price	Stock
50 mg	€80.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 50 mg	€120.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1687	(±)-E-Homocamptothecin	Potent topoisomerase I (Topo 1) inhibitor	€120.00
2100	Trovafloxacin mesylate	Inhibitor of bacterial DNA gyrase and Topo IV	€110.00
2198	Genz 644282	Topo I inhibitor lacking MDR1 and BCRP affinity	€95.00
2242	Levofloxacin Q-acid	Inhibitor of bacterial DNA gyrase and topoisomerase IV	€55.00
2391	CS1	TOPO IIα inhibitor with broad-spectrum in vitro antitumor effects	€135.00
2914	TAS-103 dihydrochloride	Dual inhibitor of topoisomerase I (Topo 1) and topoisomerase II (Topo 2)	€95.00
3171	Gatifloxacin hydrochloride	Inhibitor of bacterial DNA gyrase and topoisomerase IV	€50.00
4072	Doxorubicin hydrochloride	A cytotoxic anthracycline antibiotic	Inquire

Customer Support

Customer Services

About Axon Medchem

Contact Us

Irinotecan hydrochloride - CPT-11 | Camptothecin 11

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

Irinotecan hydrochloride - CPT-11 | Camptothecin 11

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us