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Axon 3293
CAS [296771-07-8]
MF C16H11ClN6OSMW 370.82
dCeMM2 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12:cyclin K with a CRL4B ligase complex. The pronounced destabilization of cyclin K by dCeMM2 occurred alongside a milder destabilization of both associated kinases CDK12 and CDK13.
KEYWORDS: dCeMM2 | Supplier | Glue degrader | CAS [296771-07-8] | Protein degradation | Ubiquitin Ligase (E3; other) | Degrader | Enzymes | Molecular glue degrader
2-(5H-[1,2,4]Triazino[5,6-b]indol-3-ylthio)-N-(5-chloropyridin-2-yl)acetamide
[296771-07-8]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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