Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3277

CAS [5358-76-9]

MF C20H19N3O
MW 317.38

  • Purity: 98%
  • Soluble in 0.1 HCl(aq) and DMSO



NSC194598 is a p53 DNA-binding inhibitor with an in vitro IC50 value of 180 nM. NSC194598 selectively inhibited DNA binding by p53 and homologs p63/p73, but did not affect E2F1, TCF1, and c-Myc. Furthermore, NSC194598 suppressed p53 transcriptional output after DNA damage in culture and increased the survival of mice after irradiation.

KEYWORDS: NSC194598 | supplier | p53 inhibitor | NSC 194598 | NSC-194598 | CAS [5358-76-9] | [5358-77-0] | Non Selective | p53 | Inhibitor | Transcription Factors | Alzheimer’s disease | Parkinson’s disease | Stroke | Radiation | Chemotherapy

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5 mg €130.00 In Stock
25 mg €460.00 In Stock
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2 x 5 mg €220.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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