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NSC194598
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C20H19N3O
- MW: 317.38
Description
NSC194598 is a p53 DNA-binding inhibitor with an in vitro IC50 value of 180 nM. NSC194598 selectively inhibited DNA binding by p53 and homologs p63/p73, but did not affect E2F1, TCF1, and c-Myc. Furthermore, NSC194598 suppressed p53 transcriptional output after DNA damage in culture and increased the survival of mice after irradiation.
More Information
| Parent CAS No. | 5358-76-9 |
|---|---|
| Chemical Name | 2-(Piperidin-1-ylmethyl)indeno[1,2,3-de]quinazoline 1-oxide |
| SMILES | [N+]1([O-])C2C3C=CC=CC=3C3C=2C(C=CC=3)=NC=1CN1CCCCC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C20H19N3O/c24-23-18(13-22-11-4-1-5-12-22)21-17-10-6-9-15-14-7-2-3-8-16(14)20(23)19(15)17/h2-3,6-10H,1,4-5,11-13H2 |
| InChiKey | XLBPYZGSLNDDSB-UHFFFAOYSA-N |
| CID | 3246550 |
| Short Description | p53 inhibitor |
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