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VU0486846
- Optical Purity: 100% e.e.
- Soluble in DMSO
- MF: C25H28N4O3
- MW: 432.51
Description
VU0486846 is a highly selective M1 muscarinic acetylcholine receptor (M1 mAChR) positive allosteric modulator with an EC50 value of 0.31 μM.
VU0486846 is reported to be devoid of agonist activity in the prefrontal cortex and lacks cholinergic or other adverse effects in mice, rats, and non-human primates. It produces robust procognitive activity in rodent models, making it useful for research on cholinergic signaling and cognition.
Key Features
- Highly selective M1 mAChR PAM
- EC50: 0.31 μM
- Orally active, CNS-penetrant
- No reported agonist activity in the prefrontal cortex
- Shows procognitive activity in rodent models
Applications
- M1 mAChR and CHRM1 receptor research
- CNS and Cholinergic signaling studies
- Cognitive enhancement and memory studies
- Schizophrenia and neuropsychiatric disease models
- GPCR allosteric modulator studies
More Information
| Parent CAS No. | 1788055-11-7 |
|---|---|
| Chemical Name | (R)-4-(4-(1H-Pyrazol-1-yl)benzyl)-N-((1S,2S)-2-hydroxycyclohexyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide |
| SMILES | C12O[C@@H](C(N[C@H]3CCCC[C@@H]3O)=O)CN(CC3C=CC(N4N=CC=C4)=CC=3)C1=CC=CC=2 |&1:2,5,10,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C25H28N4O3/c30-22-8-3-1-6-20(22)27-25(31)24-17-28(21-7-2-4-9-23(21)32-24)16-18-10-12-19(13-11-18)29-15-5-14-26-29/h2,4-5,7,9-15,20,22,24,30H,1,3,6,8,16-17H2,(H,27,31)/t20-,22-,24+/m0/s1 |
| InChiKey | LZCHTDQRMCSDSE-ODGPQVTHSA-N |
| CID | 118124117 |
| Short Description | M1 PAM |
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