Based on 2 reference(s) in Google Scholar 8 10 2

Axon 3271

CAS [1788055-11-7]

MF C25H28N4O3
MW 432.51

  • Purity: 99%
  • Optical purity: 100% e.e.
  • Soluble in DMSO



VU0486846 is a potent and highly selective M1 PAM (EC50 value of 0.31 μM, 85%), devoid of agonist activity in the PFC, as well as cholinergic or other adverse effects in mice, rats and NHP, which results in robust procognitive activity in rodent models.

KEYWORDS: VU0486846 | supplier | M1 PAM | VU 0486846 | VU-0486846 | CAS [1788055-11-7] | Acetylcholine | CHRM1 | PAM | Receptors | Schizophrenia

Potent and highly selective PAM of M1 mAChR

Chemical name


Parent CAS No.


Size Unit Price Stock
5 mg €165.00 In Stock
25 mg €620.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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