Lumacaftor - VX-809

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3234

CAS [936727-05-8]

MF C24H18F2N2O5
MW 452.41

Purity: 99%
Soluble in 0.1N NaOH(aq) and DMSO

Lumacaftor

Description

Lumacaftor is an efficacious and selective CFTR corrector. Lumacaftor was orally bioavailable in rats and achieved in vivo plasma levels significantly above concentrations required for in vitro efficacy.

FV Goor et al. Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. Proc Natl Acad Sci USA. 2011 Nov 15;108(46):18843-8.

Selective and orally bioavailable CFTR corrector

Chemical name

3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid

Parent CAS No.

[936727-05-8]

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Lumacaftor - VX-809

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Lumacaftor - VX-809

Description

Chemical name

Parent CAS No.

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