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HS-243
Axon 3217
CAS:
848249-10-5
Purity:
100%
- Soluble in DMSO
- MF: C17H16N4O3
- MW: 324.33
Description
HS-243 is a highly potent and selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) with IC50 values of 24 and 20 nM for IRAK-1 and IRAK-4, respectively. HS-243 specifically inhibits intracellular IRAKs without TAK1 inhibition.
More Information
| Parent CAS No. | 848249-10-5 |
|---|---|
| Chemical Name | 3-Nitro-N-(1-propyl-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide |
| SMILES | C1C=C2N/C(=NC(=O)C3C=CC=C([N+]([O-])=O)C=3)/N(CCC)C2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H16N4O3/c1-2-10-20-15-9-4-3-8-14(15)18-17(20)19-16(22)12-6-5-7-13(11-12)21(23)24/h3-9,11H,2,10H2,1H3,(H,18,19,22) |
| InChiKey | JLLIANWHDQWCMY-UHFFFAOYSA-N |
| CID | 4800865 |
| Short Description | IRAK-1/4 inhibitor |
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