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ML277
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C23H25N3O4S2
- MW: 471.59
Description
ML277 is a potent and selective Kv7.1 (KCNQ1) potassium channel activator with an EC50 value of 260 nM. ML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel.
More Information
| Parent CAS No. | 1401242-74-7 |
|---|---|
| Chemical Name | (R)-N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide |
| SMILES | C1C(S(=O)(=O)N2CCCC[C@@H]2C(NC2SC=C(C3C=CC(OC)=CC=3)N=2)=O)=CC=C(C)C=1 |&1:10,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-21(26)22(27)25-23-24-20(15-31-23)17-8-10-18(30-2)11-9-17/h6-13,15,21H,3-5,14H2,1-2H3,(H,24,25,27)/t21-/m1/s1 |
| InChiKey | OXQNLLVUVDAEHC-OAQYLSRUSA-N |
| CID | 53347902 |
| Short Description | KCNQ1 activator |
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