TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9. TC11 also showed in vivo activity against multiple myeloma cell line KMS34 tumor xenografts in ICR/SCID mice. Nucleophosmin 1 (NPM/B23) was identified as a target of TC11 for inducing apoptosis of tumor cells. Moreover, TC11 induces disruption of tubulin polymerization leading to mitotic arrest and promotes degradation of anti-apoptotic protein, MCL1, by sustained CDK1 activation.

KEYWORDS: TC11 | supplier | Apoptosis inducer | CLT-003 | TC 11 | TC-11 | CLT003 | CLT 003 | CAS [100823-03-8] | Cell Cycle Regulation | Non Selective | Inducer | Multiple myeloma | Nucleophosmin 1 | NPM