TC11 - CLT-003

Based on 26 reference(s) in Google Scholar 8 10 26

Axon 3149

CAS [100823-03-8]

MF C20H22N2O2
MW 322.40

  • Purity: 98%
  • Soluble in DMSO
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TC11

Description

TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9. TC11 also showed in vivo activity against multiple myeloma cell line KMS34 tumor xenografts in ICR/SCID mice. Nucleophosmin 1 (NPM/B23) was identified as a target of TC11 for inducing apoptosis of tumor cells. Moreover, TC11 induces disruption of tubulin polymerization leading to mitotic arrest and promotes degradation of anti-apoptotic protein, MCL1, by sustained CDK1 activation.

KEYWORDS: TC11 | supplier | Apoptosis inducer | CLT-003 | TC 11 | TC-11 | CLT003 | CLT 003 | CAS [100823-03-8] | Cell Cycle Regulation | Non Selective | Inducer | Multiple myeloma | Nucleophosmin 1 | NPM

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50 mg €360.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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