Raltegravir - MK-0518

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3120

CAS [518048-05-0]

MF C20H21FN6O5
MW 444.42

Purity: 99%
Soluble in DMSO

Raltegravir

Description

Raltegravir is a potent, selective and orally bioavailable HIV-integrase inhibitor with an IC50 value of 0.015 μM for inhibition of strand transfer. Also, Raltegravir showed potency in a cell based assay with CIC95 values of 0.019 and 0.031 µM in 10% FBS and 50% NHS, respectively.

KEYWORDS: Raltegravir | supplier | HIV integrase inhibitor | MK-0518 | MK0518 | MK 0518 | CAS [518048-05-0] | DNA | HIV | Inhibitor | Enzymes | AIDS

M Markowitz et al. Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals. J Acquir Immune Defic Syndr. 2006 Dec 15;43(5):509-15.

V Summa et al. Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection. J Med Chem. 2008 Sep 25;51(18):5843-55.

Potent, selective and orally bioavailable HIV integrase inhibitor

Chemical name

N-(2-(4-(4-Fluorobenzylcarbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)-5-methyl-1,3,4-oxadiazole-2-carboxamide

Parent CAS No.

[518048-05-0]

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Raltegravir - MK-0518

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