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Axon 2933
CAS [1807988-47-1]
MF C26H23FN8OMW 482.51
IITZ-01 is a potent lysosomotropic autophagy inhibitor which has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo. Screening against the growth of cancer cell lines MCF-7, MDAMB-231, PC-3, DU-145, HT-29 and HGC-27 gave IC50 values of 1.0 µM, 1.5 µM, 0.8 µM, 1.0 µM, 1.1 µM, 0.8 µM, respectively.
KEYWORDS: IITZ-01 | supplier | Autophagy inhibitor | IITZ 01 | IITZ01 | CAS [1807988-47-1] | Cellular Metabolic Homeostasis | Lysosomotropic | Inhibitor | Apoptosis | Malaria | Triple-negative breast cancer | TNBC
N2-(4-(1H-Benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine
[1807988-47-1]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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