BAY 1895344

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2918

CAS [1876467-74-1 ]

MF C20H21N7O
MW 375.43

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in 0.1N HCl(aq) and DMSO
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BAY 1895344

Description

BAY 1895344 is a potent, highly selective and orally available ATR inhibitor (IC50 value of 7 nM), which potently inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 value of 78 nM). BAY 1895344 exhibits strong in vivo anti-tumor efficacy in monotherapy in a variety of xenograft models of different indications that are characterized by DDR deficiencies, inducing stable disease in ovarian and colorectal cancer or even complete tumor remission in mantle cell lymphoma models.

KEYWORDS: BAY 1895344 | supplier | ATR inhibitor | BAY1895344 | BAY-1895344 | CAS [1876467-74-1] | DNA-damage response | ATR | Inhibitor | Enzymes | Ovarian | Colorectal | Mantle cell lymphoma 

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5 mg €100.00 In Stock
25 mg €325.00 In Stock
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2 x 5 mg €160.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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