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KDU691
Axon 2845
CAS:
1513879-19-0
Purity:
99%
- Soluble in DMSO
- MF: C22H18ClN5O2
- MW: 419.86
Description
KDU691 is an inhibitor of Plasmodium phosphatidylinositol 4-kinase (PI4K) with activity against multiple parasite liver stages. Reported IC50 values are 0.18 µM against hypnozoite forms and 0.061 µM against liver schizonts.
KDU691 also inhibits blood-stage parasites, including dihydroartemisinin-pretreated ring stages, and has demonstrated causal prophylactic activity in primate malaria models. Although it suppresses developing liver stages, in vivo studies indicate that Plasmodium PI4K inhibition alone does not reliably eliminate established dormant hypnozoites and should not be interpreted as validated radical-cure activity.
Key Features
- Plasmodium PI4K inhibitor
- IC50: 0.18 µM against hypnozoites
- IC50: 0.061 µM against liver schizonts
- Active against liver and blood stages
- Demonstrates causal prophylactic activity
Applications
- Plasmodium PI4K research
- Liver-stage malaria assays
- Hypnozoite biology
- Blood-stage parasite studies
- Causal prophylaxis and relapse research
More Information
| Parent CAS No. | 1513879-19-0 |
|---|---|
| Chemical Name | N-(4-Chlorophenyl)-N-methyl-3-(4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide |
| SMILES | C1C=C(N(C)C(=O)C2N=CC3=NC=C(C4C=CC(C(NC)=O)=CC=4)N3C=2)C=CC=1Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C22H18ClN5O2/c1-24-21(29)15-5-3-14(4-6-15)19-11-26-20-12-25-18(13-28(19)20)22(30)27(2)17-9-7-16(23)8-10-17/h3-13H,1-2H3,(H,24,29) |
| InChiKey | TYMFFISSODJRDV-UHFFFAOYSA-N |
| CID | 90157166 |
| Short Description | PI4K inhibitor |
KDU691
plasmodium PI4K inhibitor
KDU-691
KDU 691
Phosphatidylinositol
PI4K
Plasmodium
plasmodium PI4K
Inhibitor
Plasmodium PI4K research
Liver-stage malaria assays
Hypnozoite biology
Blood-stage parasite studies
Causal prophylaxis and relapse research
kinase signaling
drug discovery
enzyme pharmacology
CAS 1513879-19-0
Axon Medchem
Axon 2845
Supplier
Vendor
References
- AM Zeeman et al. PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2858-63.
- L Dembele et al. The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites. Sci Rep. 2017 May 24;7(1):2325.
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