SHP1 inhibitor TPI-1 (IC50 value 40 nM) selectively increased SHP1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulated by phosphatases SHP2 or CD45, respectively. TPI-1 was shown to be more effective than sodium stibogluconate in SHP1 inhibition, immune cell activation and anti-tumor action.

KEYWORDS: TPI-1 | supplier | SHP1 inhibitor | TPI1 | TPI 1 | CAS [ 79756-69-7 ] | Non Selective (Tyrosine Specific Phosphomonoesters) | SHP | Inhibitor | Enzymes | SHP-1 | tyrosine phosphatase inhibitor-1 | cancer | anti-tumor