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SUVN-502
- Masupirdine
- Parent CAS: 701205-60-9
- Soluble in water and DMSO
- MF: C23H32BrN3O9S3
- MW: 670.61
Description
SUVN-502 (Masupirdine) is a potent, selective and orally active antagonist of the serotonin 5-HT6 receptor with a Ki value of 2.04 nM. It shows high selectivity across a broad receptor, enzyme, transporter and ion-channel panel, including substantial selectivity over 5-HT2A receptors.
SUVN-502 is brain-penetrant and has been used to investigate the contribution of 5-HT6 receptor signaling to cognition, neurotransmitter release and neuronal network function.
Key Features
- High-affinity 5-HT6 receptor antagonist
- Ki: 2.04 nM
- Orally active and brain-penetrant
- Broad off-target selectivity profile
Applications
- 5-HT6 receptor pharmacology
- Serotonergic signaling studies
- Cognition and memory research
- Behavioral neuroscience
- Neurotransmitter-release studies
More Information
| Parent CAS No. | 701205-60-9 |
|---|---|
| Chemical Name | 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole bismesylate |
| SMILES | C1(S(=O)(=O)N2C3C=CC(OC)=CC=3C(CN3CCN(C)CC3)=C2)C=CC=CC=1Br.CS(O)(=O)=O.CS(O)(=O)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C21H24BrN3O3S.2CH4O3S/c1-23-9-11-24(12-10-23)14-16-15-25(20-8-7-17(28-2)13-18(16)20)29(26,27)21-6-4-3-5-19(21)22;2*1-5(2,3)4/h3-8,13,15H,9-12,14H2,1-2H3;2*1H3,(H,2,3,4) |
| InChiKey | LOZVXBFXRPRECW-UHFFFAOYSA-N |
| CID | 118142730 |
| Short Description | 5-HT6 antagonist |
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