ZB716 is a steroidal, orally bioavailable SERD (selective estrogen receptor downregulator) that binds to ER with high affinity and exerts its antiestrogenic effect on ER-expressing breast cancer cells. In both tamoxifen-naive and tamoxifen-resistant breast cancer cells, ZB716 potently inhibits cell proliferation and effectively degrades the hormone receptor in a dose-dependent manner. ZB716 is shown to have far superior oral bioavailability in mice when compared to fulvestrant.
* Sold in collaboration with Zenopharm, LLC
KEYWORDS: ZB716 | supplier | SERD | ZB-716 | CAS [1853279-29-4] | Estrogen | Estrogen (ER) | Downregulator | selective estrogen receptor downregulator | nuclear | steroidal | breast cancer | cell proliferation