ZB716

Based on 2 reference(s) in Google Scholar 9 10 2

Axon 2652

CAS [1853279-29-4]

MF C32H48BF5O4S
MW 634.59

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO
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ZB716

Description

ZB716 is a steroidal, orally bioavailable SERD (selective estrogen receptor downregulator) that binds to ER with high affinity and exerts its antiestrogenic effect on ER-expressing breast cancer cells. In both tamoxifen-naive and tamoxifen-resistant breast cancer cells, ZB716 potently inhibits cell proliferation and effectively degrades the hormone receptor in a dose-dependent manner. ZB716 is shown to have far superior oral bioavailability in mice when compared to fulvestrant.

* Sold in collaboration with Zenopharm, LLC

KEYWORDS: ZB716 | supplier | SERD | ZB-716 | CAS [1853279-29-4] | Estrogen | Estrogen (ER) | Downregulator | selective estrogen receptor downregulator | nuclear | steroidal | breast cancer | cell proliferation

Steroidal, orally bioavailable SERD

Chemical name

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ylboronic acid

Source information

Sold in collaboration with Zenopharm, LLC

Parent CAS No.

[1853279-29-4]

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Size Unit Price Stock
2 mg €125.00 In Stock
5 mg €205.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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