CYP1B1 inhibitor (IC50 values 6 nM, 300 nM, and 3100 nM for inhibition of CYP1B1, CYP1A1, and CYP1A2, resp.), that potentiates the inhibition of cell growth and induces apoptosis in human cancer cells. Moreover, TMS is a useful compound for characterizing the enzymatic properties of CYP1B1 and its contribution to hypertension and associated pathophysiology.

KEYWORDS: TMS | supplier | CYP1B1 inhibitor | Trans-2,3',4,5'-tetramethoxystilbene | tetramethoxystilbene | CAS [24144-92-1] | Cytochrome P450 | Aryl hydrocarbon hydroxylase | cell growth | apoptosis | cancer | hypertension | cardiovascular