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TMS
- Trans-2,3',4,5'-tetramethoxystilbene
- Soluble in DMSO
- MF: C18H20O4
- MW: 300.35
Description
CYP1B1 inhibitor (IC50 values 6 nM, 300 nM, and 3100 nM for inhibition of CYP1B1, CYP1A1, and CYP1A2, resp.), that potentiates the inhibition of cell growth and induces apoptosis in human cancer cells. Moreover, TMS is a useful compound for characterizing the enzymatic properties of CYP1B1 and its contribution to hypertension and associated pathophysiology.
More Information
| Parent CAS No. | 24144-92-1 |
|---|---|
| Chemical Name | (E)-4,5'-(ethene-1,2-diyl)bis(1,3-dimethoxybenzene) |
| SMILES | C1(/C=C/C2=CC(OC)=CC(OC)=C2)=CC=C(OC)C=C1OC |
| MFCD | MFCD03428621 |
| InChi | InChI=1S/C18H20O4/c1-19-15-8-7-14(18(12-15)22-4)6-5-13-9-16(20-2)11-17(10-13)21-3/h5-12H,1-4H3/b6-5+ |
| InChiKey | JDBCWSHYEQUBLW-AATRIKPKSA-N |
| CID | 5354004 |
| Short Description | CYP1B1 inhibitor |
References
- S Kim et al. Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. J Med Chem. 2002 Jan 3;45(1):160-4.
- KA Nam et al. Resveratrol analog, 3,5,2',4'-tetramethoxy-trans-stilbene, potentiates the inhibition of cell growth and induces apoptosis in human cancer cells. Arch Pharm Res. 2001 Oct;24(5):441-5.
- KU Malik et al. Contribution of cytochrome P450 1B1 to hypertension and associated pathophysiology: a novel target for antihypertensive agents. Prostaglandins Other Lipid Mediat. 2012 Aug;98(3-4):69-74.
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