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ZQ-16
Axon 2616
CAS:
376616-73-8
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C10H16N2O2S
- MW: 228.31
Description
Potent and selective small-molecule GPR84 agonist (EC50 value 0.139 µM in a calcium mobilization assay). ZQ-16 induced phosphorylation of ERK1/2, and a dose-dependent reduction of forskolin-stimulated cAMP accumulation in HEK293 cells expressing GPR84.
More Information
| Parent CAS No. | 376616-73-8 |
|---|---|
| Chemical Name | 2-(hexylthio)pyrimidine-4,6-diol |
| SMILES | C1(SCCCCCC)=NC(O)=CC(O)=N1 |
| MFCD | N.A. |
| InChi | InChI=1S/C10H16N2O2S/c1-2-3-4-5-6-15-10-11-8(13)7-9(14)12-10/h7H,2-6H2,1H3,(H2,11,12,13,14) |
| InChiKey | UYXOAKRMLQKLQX-UHFFFAOYSA-N |
| CID | 1912564 |
| Short Description | GPR84 agonist |
References
- Q Zhang et al. Discovery and Characterization of a Novel Small-Molecule Agonist for Medium-Chain Free Fatty Acid Receptor G Protein-Coupled Receptor 84. J Pharmacol Exp Ther. 2016 May;357(2):337-44.
- Y Liu et al. Design and Synthesis of 2-Alkylpyrimidine-4,6-diol and 6-Alkylpyridine-2,4-diol as Potent GPR84 Agonists. ACS Med Chem Lett. 2016 Mar 30;7(6):579-83.
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