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ZQ-16
Axon 2616
CAS:
376616-73-8
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C10H16N2O2S
- MW: 228.31
Description
ZQ-16 is a potent and selective agonist of G-protein coupled receptor 84 (GPR84). It activates GPR84 (EC50: 134–139 nM for cAMP; 0.213 µM for calcium mobilization) with high selectivity and has no cross-activity at 100 µM against related FFARs including GPR40, GPR41, GPR119, or GPR120. ZQ-16 induced phosphorylation of ERK1/2, and a dose-dependent reduction of forskolin-stimulated cAMP accumulation in HEK293 cells expressing GPR84.
GPR84 pharmacology is central to inflammatory signaling. ZQ-16 serves as a key tool supporting mechanistic studies of GPR84, free fatty acids (FFAs), and ERK1 pathways across biochemical, cellular, and disease-model assays.
Key Features
- Potent and selective GPR84 agonist
- Activates GPR84 (EC50: 134 nM for cAMP)
- Highly selective over related FFARs
- Potent and selective small-molecule GPR84 agonist (EC50 value 0.139 µM in a calcium mobilization assay)
Applications
- GPR84 pharmacology and target-validation studies
- GPR84 pathway and signaling assays
- Disease-model research related to inflammation
- Receptor signaling, ligand profiling and functional response assays
More Information
| Parent CAS No. | 376616-73-8 |
|---|---|
| Chemical Name | 2-(hexylthio)pyrimidine-4,6-diol |
| SMILES | C1(SCCCCCC)=NC(O)=CC(O)=N1 |
| MFCD | N.A. |
| InChi | InChI=1S/C10H16N2O2S/c1-2-3-4-5-6-15-10-11-8(13)7-9(14)12-10/h7H,2-6H2,1H3,(H2,11,12,13,14) |
| InChiKey | UYXOAKRMLQKLQX-UHFFFAOYSA-N |
| CID | 1912564 |
| Short Description | GPR84 agonist |
ZQ-16
selective GPR84 agonist
ZQ16
GPR84
ERK1
ERK3
Agonist
cAMP signaling
GPR84 pharmacology
GPR84 signaling assays
inflammation
receptor signaling and ligand profiling
lipid metabolism
receptor selectivity
signal transduction
receptor pharmacology
immunology
GPCR
cAMP
CAS 376616-73-8
Axon Medchem
Axon 2616
Supplier
Vendor
References
- Q Zhang et al. Discovery and Characterization of a Novel Small-Molecule Agonist for Medium-Chain Free Fatty Acid Receptor G Protein-Coupled Receptor 84. J Pharmacol Exp Ther. 2016 May;357(2):337-44.
- Y Liu et al. Design and Synthesis of 2-Alkylpyrimidine-4,6-diol and 6-Alkylpyridine-2,4-diol as Potent GPR84 Agonists. ACS Med Chem Lett. 2016 Mar 30;7(6):579-83.
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