Bulk Inquiry
KPT 335
- Verdinexor
- Soluble in DMSO
- MF: C18H12F6N6O
- MW: 442.32
Description
Orally bioavailable selective inhibitor of nuclear export (SINE; Exportin-1 or XPO1 inhibitor; IC50 values 2.1 nM, 41.8 nM, and 8.5 nM, for inhibition of the viability of OCI-Ly3, OCI-Ly10, and CLBL1, respectively). Verdinexor (KPT 335) potently and selectively inhibits vRNP export and effectively inhibits the replication of various influenza virus A and B strains in vitro and in vivo. KPT 335 induced apoptosis in CLBL1 cells and primary canine DLBCL cells indicating good in vitro single agent activity against canine malignant melanoma.
More Information
| Parent CAS No. | 1392136-43-4 |
|---|---|
| Chemical Name | (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyridin-2-yl)acrylohydrazide |
| SMILES | C(/N1C=NC(C2C=C(C(F)(F)F)C=C(C(F)(F)F)C=2)=N1)=C/C(NNC1N=CC=CC=1)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C18H12F6N6O/c19-17(20,21)12-7-11(8-13(9-12)18(22,23)24)16-26-10-30(29-16)6-4-15(31)28-27-14-3-1-2-5-25-14/h1-10H,(H,25,27)(H,28,31)/b6-4- |
| InChiKey | OPAKEJZFFCECPN-XQRVVYSFSA-N |
| CID | 71492799 |
| Short Description | XPO1/CRM1 inhibitor |
References
- CA London et al. Preclinical evaluation of the novel, orally bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in spontaneous canine cancer: results of a phase I study. PLoS One. 2014 Feb 4;9(2):e87585.
- K Parikh et al. Selective inhibitors of nuclear export (SINE)--a novel class of anti-cancer agents. J Hematol Oncol. 2014 Oct 15;7:78.
- MN Breit et al. Biologic activity of the novel orally bioavailable selective inhibitor of nuclear export (SINE) KPT-335 against canine melanoma cell lines. BMC Vet Res. 2014 Jul 15;10:160.
- O Perwitasari et al. Verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo. J Virol. 2014 Sep 1;88(17):10228-43.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 2336 | KPT-330 |
From $99.00 |
| 3110 | Remdesivir |
From $99.00 |
| 3136 | Oseltamivir phosphate |
From $66.00 |
| 3140 | Arbidol hydrochloride |
From $66.00 |
| 3141 | DHQZ 36 |
From $132.00 |
| 3173 | Velpatasvir |
From $55.00 |
| 3188 | MK-4482 |
From $104.50 |
| 3241 | Ganciclovir |
From $66.00 |
| 3360 | CBS1117 |
From $121.00 |
| 3384 | Acyclovir |
From $66.00 |
| 3385 | Penciclovir |
From $66.00 |
| 3573 | Ribavirin |
From $66.00 |
Other Categories
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.