KPT 335 - Verdinexor

Based on 65 reference(s) in Google Scholar 9 10 65

Axon 2597

CAS [1392136-43-4]

MF C18H12F6N6O
MW 442.32

  • Purity: 99%
  • Soluble in DMSO

KPT 335

Description

Orally bioavailable selective inhibitor of nuclear export (SINE; Exportin-1 or XPO1 inhibitor; IC50 values 2.1 nM, 41.8 nM, and 8.5 nM, for inhibition of the viability of OCI-Ly3, OCI-Ly10, and CLBL1, respectively). Verdinexor (KPT 335) potently and selectively inhibits vRNP export and effectively inhibits the replication of various influenza virus A and B strains in vitro and in vivo. KPT 335 induced apoptosis in CLBL1 cells and primary canine DLBCL cells indicating good in vitro single agent activity against canine malignant melanoma.

KEYWORDS: KPT 335 | supplier | XPO1/CRM1 inhibitor | Verdinexor | KPT335 | CAS [1392136-43-4] | [1421923-73-0] | DNA-RNA | Exportin-1 | CRM1 | canine | melanoma | influenza | nuclear export | transporter | chaperone

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5 mg €105.00 In Stock
25 mg €365.00 In Stock
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2 x 25 mg €560.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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